Quantitative Diffusion Tensor Imaging Tractography Metrics are Associated with Cognitive Performance Among HIV-Infected Patients | SpringerLink louboutin för män

Quantitative Diffusion Tensor Imaging Tractography Metrics are Associated with Cognitive Performance Among HIV-Infected Patients

  • Authors
  • Authors and affiliations
  • David F. TateEmail author
  • Jared Conley
  • Robert H. Paul
  • Kathryn Coop
  • Song Zhang
  • Wenjin Zhou
  • David H. Laidlaw
  • Lynn E. Taylor
  • Timothy Flanigan
  • Bradford Navia
  • Ronald Cohen
  • Karen Tashima
  • 24 Citations
Насосы2 class="Heading">Abstract

There have been many studies examining HIV-infection-related alterations of magnetic resonance imaging (MRI) diffusion metrics. However, examining scalar diffusion metrics ignores the orientation aspect of diffusion imaging, which can be captured with tractography. We examined five different tractography metrics obtained from global tractography maps (global tractography FA, average tube length, normalized number of streamtubes, normalized weighted streamtube length, and normalized total number of tubes generated) for differences between HIV positive and negative patients and the association between the metrics and clinical variables of disease severity. We also examined the relationship between these metrics and cognitive performance across a wide range of cognitive domains for the HIV positive and negative patient groups separately. The results demonstrated a significant difference between the groups for global tractography FA (t = 2.13, p = 0.04), but not for any of the other tractography metrics examined (p-value range = 0.39 to 0.95). There were also several significant associations between the tractography metrics and cognitive performance (i.e., tapping rates, switching 1 and 2, verbal interference, mazes; r ≥ 0.42) for HIV infected patients. In particular, associations were noted between tractography metrics, speed of processing, fine motor control/speed, and executive function for the HIV-infected patients. These findings suggest that tractography metrics capture clinically relevant information regarding cognitive performance among HIV infected patients and suggests the importance of subtle white matter changes in examining cognitive performance.


HIV DTI Neuropsychological performance Tractography 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • David F. Tate
    • 1
    • 2
  • Jared Conley
    • 1
  • Robert H. Paul
    • 3
  • Kathryn Coop
    • 4
  • Song Zhang
    • 5
  • Wenjin Zhou
    • 6
  • David H. Laidlaw
    • 6
  • Lynn E. Taylor
    • 4
    • 7
  • Timothy Flanigan
    • 4
    • 7
  • Bradford Navia
    • 8
  • Ronald Cohen
    • 9
  • Karen Tashima
    • 4
    • 7
  1. 1.Departments of Radiology and Psychiatry, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  2. 2.Department of Neurology, Boston University Medical Center Alzheimer’s Disease CenterBoston University Medical SchoolBostonUSA
  3. 3.Department of PsychologyUniversity of Missouri at St. LouisSt. LouisUSA
  4. 4.Center for AIDS ResearchThe Miriam HospitalProvidenceUSA
  5. 5.Department of Computer Science and EngineeringMississippi State UniversityStarkvilleUSA
  6. 6.Department of Computer ScienceBrown UniversityProvidenceUSA
  7. 7.Department of MedicineThe Warren Alpert Medical School at Brown UniversityProvidenceUSA
  8. 8.Department of MedicineTufts New England Medical CenterBostonUSA
  9. 9.Department of Psychiatry and Behavioral MedicineThe Warren Alpert School of Medicine at Brown UniversityProvidenceUSA

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Dia dos irmãos!

Maio 31, 2016 183 Comentários

O mês de maio é o mês de Maria e o mês das famílias. É também em Maio que festejamos o dia dos irmãos. ❤️

Para quem não sabe, ainda fui filha única durante algum tempo – quase 8 anos – muito tempo! Lembro-me bem quando os meus pais me disseram que ia ter um irmão ou irmã – fiquei tão feliz! Um bebé para eu brincar, tal como eu brincava com as minhas bonecas, era tudo o que eu queria! E a verdade é que desde que nasceram os meus irmãos a minha vida ficou muito mais rica e feliz.

Para mim foi sem dúvida o melhor presente que os meus pais me deram até hoje, daí eu sempre querer ter mais do que um filho, mal sabia eu que viriam quatro e tão rápido! heheh

Orgulho-me de dizer que sou a maior fã dos meus irmãos. Vivo as suas alegrias, vitórias, tristezas e preocupações como se fossem minhas. Tenho muita sorte de ter irmãos espectaculares que me ajudam em tudo e que estão sempre no meu caminho, em todos os bons e maus momentos, sempre com uma mão estendida para me ajudarem nesta longa caminhada que é a vida!

Posso-vos dizer que, sem eles, a minha aventura de ser mãe de quatro bebés tão próximos não seria passível de ser desempenhada com tanta facilidade. Tenho a sorte de os ter sempre por perto e de me ajudarem muito, são uns irmãos e tios espectaculares. Orgulho em ter irmãos tão especiais e que são tão bons exemplos – se os meus filhos se tornarem em pessoas «parecidas» vou ser uma mãe muito orgulhosa!

Acho que se não tivesse a sorte de ter tido os meus irmãos não seria uma pessoa tão rica e feliz, ter irmãos é sem dúvida uma das melhores coisas que podemos ter.

Sou feliz e mais completa por saber que já dei aos meus filhos essa alegria. Todos os dias que passam e que vejo a relação deles a crescer fico mais feliz e comovida. É lindo vê-los crescer e ver a relação que estão a criar. É bom ver o cuidado e a preocupação que vejo na Matilde e no Tomás com as manas e ver que esse sentimento vai aumentando de dia para dia.

Espero que sejam sempre tão amigos como eu sou dos meus irmãos e que se ajudem muito pela vida fora!


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